Efficiency Comparison Between 99mTc-tetrofosmin and 99mTc-sestamibi Myocardial Perfusion Studies

C.G. Ravizzini, M.W. Hanson, L.K. Shaw, T.Z. Wong, R.J. Hagge, R.A. Pagnanelli, D. Jain, H.S. Lima Jr, R.E. Coleman, and S. Borges-Neto As published in Nuclear Medicine Communications

Efficiency Evaluation of MYOVIEW (technetium Tc99m tetrofosmin) and Cardiolite ® (Tc99m Sestamibi)¹

Objective

• Investigation to assess the efficiency of imaging protocols using two different 99mTc-labeled myocardial perfusion tracers, MYOVIEW and Cardiolite

Methodology

• 1,134 SPECT imaging studies performed
• Alternating use between both tracers for a total of eight months
• MYOVIEW imaging procedure:
  • – Rest studies: imaging 30-minutes postinjection
  • Stress studies: imaging 20-minutes postinjection
  • Pharmacologic stress studies: imaging 30-minutes postinjection
• Cardiolite imaging procedure:
  • Rest studies: imaging 60-minutes postinjection
  • Stress studies: imaging 30-minutes postinjection
  • Pharmacologic stress studies: imaging 45-minutes postinjection

Variables Analyzed

• Injection-to-imaging time for procedure
• Number of repeated scans due to extra cardiac activity

Efficiency Evaluation of 1,134 Imaging Studies: Injection-to-Imaging Studies¹

Study	Time (min)		P Value
	MYOVIEW	Cardiolite (Tc99m Sestamibi)
Rest	47.7 ± 21.7	74.3 ± 25.8	0.0001
Stress	42.9 ± 23.3	48.4 ± 25.0	0.0066
Rest and Stress	90.0 ± 32.7	124.0 ± 37.0	0.0001

Efficiency Evaluation of Cardiolite and MYOVIEW: Overall Re-Scan Rate Due to Liver and Combined Liver and Bowel Activity¹

Study	Time (min)		P Value
	Cardiolite	MYOVIEW
Rest	21.4 (75/351)	10.0 (26/261)	0.001
Stress	9.9 (26/263)	5.8 (15/259)	0.082
Rest and Stress	19.7 (101/514)	7.9 (41/520)	0.01

Results determined by Ravizzini et al

• Completion time for rest study significantly shorter for MYOVIEW compared with Cardiolite
• Total study time was significantly shorter with MYOVIEW than with Cardiolite
• Number of repeated scans higher with Cardiolite than with MYOVIEW
• MYOVIEW provides higher patient throughput with fewer repeat scans2

References: 1. Ravizzini GC, Hanson MW, Shaw LK, et al. Efficiency comparison between 99mTc-tetrofosmin and 99mTc-sestamibi myocardial perfusion studies. Nucl Med Comm. 2002;23:203-208. 2. MYOVIEW Prescribing Information.

Cardiolite is a registered trademark of Bristol-Myers Squibb Medical Imaging, Inc.

• Full Prescribing Information